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Monoglyceride lipase deficiency modulates endocannabinoid signaling and improves plaque stability in ApoE-knockout mice
BACKGROUND AND AIMS: Monoglyceride lipase (MGL) catalyzes the final step of lipolysis by degrading monoglyceride (MG) to glycerol and fatty acid. MGL also hydrolyzes and thereby deactivates 2-arachidonoyl glycerol (2-AG), the most abundant endocannabinoid in the mammalian system. 2-AG acts as full a...
Autores principales: | Vujic, Nemanja, Schlager, Stefanie, Eichmann, Thomas O., Madreiter-Sokolowski, Corina T., Goeritzer, Madeleine, Rainer, Silvia, Schauer, Silvia, Rosenberger, Angelika, Woelfler, Albert, Doddapattar, Prakash, Zimmermann, Robert, Hoefler, Gerald, Lass, Achim, Graier, Wolfgang F., Radovic, Branislav, Kratky, Dagmar |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704137/ https://www.ncbi.nlm.nih.gov/pubmed/26584135 http://dx.doi.org/10.1016/j.atherosclerosis.2015.10.109 |
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