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Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

BACKGROUND: Many retinal degenerative diseases are caused by the loss of retinal ganglion cells (RGCs). Autosomal dominant optic atrophy is the most common hereditary optic atrophy disease and is characterized by central vision loss and degeneration of RGCs. Currently, there is no effective treatmen...

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Detalles Bibliográficos
Autores principales:	Chen, Jing, Riazifar, Hamidreza, Guan, Min-Xin, Huang, Taosheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704249/ https://www.ncbi.nlm.nih.gov/pubmed/26738566 http://dx.doi.org/10.1186/s13287-015-0264-1

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