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PKM2 promotes tumor angiogenesis by regulating HIF-1α through NF-κB activation
BACKGROUND: Initially identified as a molecule that regulates the final step of glycolysis, the M2 isoform of pyruvate kinase (PKM2) was recently reported to have a central role in the metabolic reprogramming of cancer cells as well as participating in cell cycle progression and gene transcription....
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704385/ https://www.ncbi.nlm.nih.gov/pubmed/26739387 http://dx.doi.org/10.1186/s12943-015-0490-2 |