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Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study
BACKGROUND: Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704396/ https://www.ncbi.nlm.nih.gov/pubmed/26739690 http://dx.doi.org/10.1186/s12882-015-0218-y |
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author | Park, Minseon So, Rina Joo, Kwon Wook Yoon, Hyung-Jin |
author_facet | Park, Minseon So, Rina Joo, Kwon Wook Yoon, Hyung-Jin |
author_sort | Park, Minseon |
collection | PubMed |
description | BACKGROUND: Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF. METHODS: The health data of 41,886 adults with an estimated glomerular filtration rate (eGFR) ≥60 mL/min per 1.73 m(2) were analyzed. The eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation and RHF was defined as eGFR with adjusted residuals > sex-specific 95(th) percentile. RESULTS: The adjusted mean of eGFR was lower in the highest quintile of serum bicarbonate than in other quintiles, after adjusting for confounders. A lower percentile rank of serum bicarbonate was associated with higher odds of RHF. The odds ratio (OR) for RHF in the lowest quintile of serum bicarbonate was 1.39 (95 % confidence interval, 95 % CI, 1.11–1.75) compared to the highest, after adjusting for confounders. With subgroup analysis, the association was prominent in participants with a body mass index >25 kg/m(2) (OR 1.98, 95 % CI 1.32–2.95 in the lowest quintile compared to the highest), compared to those with a body mass index ≤25 kg/m(2) (OR 1.18, 95 % CI 0.89–1.56 in the lowest quintile compared to the highest). CONCLUSIONS: This study observed an association between lower serum bicarbonate and higher odds of RHF and the possible differential effect of obesity in this association. It is necessary to confirm the association between lower serum bicarbonate and RHF and its causality. |
format | Online Article Text |
id | pubmed-4704396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47043962016-01-08 Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study Park, Minseon So, Rina Joo, Kwon Wook Yoon, Hyung-Jin BMC Nephrol Research Article BACKGROUND: Lower serum bicarbonate, mainly due to the modern Western-style diet, and renal hyperfiltration (RHF) are both independently associated with higher mortality in the general population with preserved renal function. The objective of this study was to evaluate the association between serum bicarbonate and RHF. METHODS: The health data of 41,886 adults with an estimated glomerular filtration rate (eGFR) ≥60 mL/min per 1.73 m(2) were analyzed. The eGFR was calculated with the Chronic Kidney Disease Epidemiology Collaboration creatinine equation and RHF was defined as eGFR with adjusted residuals > sex-specific 95(th) percentile. RESULTS: The adjusted mean of eGFR was lower in the highest quintile of serum bicarbonate than in other quintiles, after adjusting for confounders. A lower percentile rank of serum bicarbonate was associated with higher odds of RHF. The odds ratio (OR) for RHF in the lowest quintile of serum bicarbonate was 1.39 (95 % confidence interval, 95 % CI, 1.11–1.75) compared to the highest, after adjusting for confounders. With subgroup analysis, the association was prominent in participants with a body mass index >25 kg/m(2) (OR 1.98, 95 % CI 1.32–2.95 in the lowest quintile compared to the highest), compared to those with a body mass index ≤25 kg/m(2) (OR 1.18, 95 % CI 0.89–1.56 in the lowest quintile compared to the highest). CONCLUSIONS: This study observed an association between lower serum bicarbonate and higher odds of RHF and the possible differential effect of obesity in this association. It is necessary to confirm the association between lower serum bicarbonate and RHF and its causality. BioMed Central 2016-01-06 /pmc/articles/PMC4704396/ /pubmed/26739690 http://dx.doi.org/10.1186/s12882-015-0218-y Text en © Park et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Park, Minseon So, Rina Joo, Kwon Wook Yoon, Hyung-Jin Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title | Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title_full | Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title_fullStr | Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title_full_unstemmed | Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title_short | Association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
title_sort | association between lower serum bicarbonate and renal hyperfiltration in the general population with preserved renal function: a cross-sectional study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704396/ https://www.ncbi.nlm.nih.gov/pubmed/26739690 http://dx.doi.org/10.1186/s12882-015-0218-y |
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