A human macrophage – hepatocyte co-culture model for comparative studies of infection and replication of Francisella tularensis LVS strain and subspecies holarctica and mediasiatica

BACKGROUND: Francisella tularensis, a gram-negative bacterium replicates intracellularly within macrophages and efficiently evades the innate immune response. It is able to infect and replicate within Kupffer cells, specialized tissue macrophages of the liver, and to modulate the immune response upo...

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Detalles Bibliográficos
Autores principales: Rennert, Knut, Otto, Peter, Funke, Harald, Huber, Otmar, Tomaso, Herbert, Mosig, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704405/
https://www.ncbi.nlm.nih.gov/pubmed/26739172
http://dx.doi.org/10.1186/s12866-015-0621-3

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