Differentiation therapy: a promising strategy for cancer treatment

Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate...

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Detalles Bibliográficos
Autores principales: Yan, Min, Liu, Quentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704415/
https://www.ncbi.nlm.nih.gov/pubmed/26739838
http://dx.doi.org/10.1186/s40880-015-0059-x
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author Yan, Min
Liu, Quentin
author_facet Yan, Min
Liu, Quentin
author_sort Yan, Min
collection PubMed
description Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate the polycomb protein enhancer of zeste homologue 2 (EZH2) as a target for intervention.
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spelling pubmed-47044152016-01-20 Differentiation therapy: a promising strategy for cancer treatment Yan, Min Liu, Quentin Chin J Cancer Perspective Poor differentiation is an important hallmark of cancer cells, and differentiation therapy holds great promise for cancer treatment. The restoration of IkB kinase α (IKKα) leads to the differentiation of nasopharyngeal carcinoma cells with reduced tumorigenicity. The findings by Yan et al. validate the polycomb protein enhancer of zeste homologue 2 (EZH2) as a target for intervention. BioMed Central 2016-01-06 /pmc/articles/PMC4704415/ /pubmed/26739838 http://dx.doi.org/10.1186/s40880-015-0059-x Text en © Yan and Liu. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Perspective
Yan, Min
Liu, Quentin
Differentiation therapy: a promising strategy for cancer treatment
title Differentiation therapy: a promising strategy for cancer treatment
title_full Differentiation therapy: a promising strategy for cancer treatment
title_fullStr Differentiation therapy: a promising strategy for cancer treatment
title_full_unstemmed Differentiation therapy: a promising strategy for cancer treatment
title_short Differentiation therapy: a promising strategy for cancer treatment
title_sort differentiation therapy: a promising strategy for cancer treatment
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704415/
https://www.ncbi.nlm.nih.gov/pubmed/26739838
http://dx.doi.org/10.1186/s40880-015-0059-x
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