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Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function

BACKGROUND: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether...

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Autores principales: Chen, Chang-Chiang, Susanto, Hendra, Chuang, Wen-Han, Liu, Ta-Yu, Wang, Chih-Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704426/
https://www.ncbi.nlm.nih.gov/pubmed/26739836
http://dx.doi.org/10.1186/s12933-015-0326-9
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author Chen, Chang-Chiang
Susanto, Hendra
Chuang, Wen-Han
Liu, Ta-Yu
Wang, Chih-Hong
author_facet Chen, Chang-Chiang
Susanto, Hendra
Chuang, Wen-Han
Liu, Ta-Yu
Wang, Chih-Hong
author_sort Chen, Chang-Chiang
collection PubMed
description BACKGROUND: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. METHODS: Based on albumin/creatinine ratio (ACR), 109 T2DM patients were divided into normoalbuminuria (ACR <30 mg/g), microalbuminuria (ACR between 30 and 300 mg/g), and macroalbuminuria (ACR > 300 mg/g). Serum betatrophin levels of 109 T2DM patients and 32 healthy subjects were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum level of betatrophin was significantly increased in T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria as compared with healthy subjects (P < 0.001). Serum betatrophin level was positively correlated with sex, duration of diabetes, systolic blood pressure (SBP), body mass index (BMI), ACR, and triglyceride, whereas it was inversely correlated with estimated glomerular filtration rate (eGFR), total cholesterol, and high-density lipoprotein cholesterol (HDL-C) (P < 0.001). Furthermore, multivariate regression analysis showed the betatrophin was significantly and positively independent with triglyceride and low-density lipoprotein cholesterol (LDL-C) (P < 0.05), whereas it was inversely independent with eGFR, total cholesterol, and low-density lipoprotein cholesterol (HDL-C) (P < 0.05). In addition, the betatrophin had higher odds of having DN [odds ratio (OR) = 5.65, 95 % confidence interval (CI) 2.17–14.57, P < 0.001]. CONCLUSION: Betatrophin is significantly increased in T2DM patients with different stages of albuminuria. Betatrophin may be a novel endocrine regulator involved in DN development.
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spelling pubmed-47044262016-01-08 Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function Chen, Chang-Chiang Susanto, Hendra Chuang, Wen-Han Liu, Ta-Yu Wang, Chih-Hong Cardiovasc Diabetol Original Investigation BACKGROUND: Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Although dysregulated lipid metabolism results in diabetic nephropathy (DN) development in patients with type 2 diabetes mellitus (T2DM), it is not understood whether betatrophin is associated with urinary albumin excretion and renal function. METHODS: Based on albumin/creatinine ratio (ACR), 109 T2DM patients were divided into normoalbuminuria (ACR <30 mg/g), microalbuminuria (ACR between 30 and 300 mg/g), and macroalbuminuria (ACR > 300 mg/g). Serum betatrophin levels of 109 T2DM patients and 32 healthy subjects were determined by enzyme-linked immunosorbent assay (ELISA). RESULTS: Serum level of betatrophin was significantly increased in T2DM patients with normoalbuminuria, microalbuminuria, and macroalbuminuria as compared with healthy subjects (P < 0.001). Serum betatrophin level was positively correlated with sex, duration of diabetes, systolic blood pressure (SBP), body mass index (BMI), ACR, and triglyceride, whereas it was inversely correlated with estimated glomerular filtration rate (eGFR), total cholesterol, and high-density lipoprotein cholesterol (HDL-C) (P < 0.001). Furthermore, multivariate regression analysis showed the betatrophin was significantly and positively independent with triglyceride and low-density lipoprotein cholesterol (LDL-C) (P < 0.05), whereas it was inversely independent with eGFR, total cholesterol, and low-density lipoprotein cholesterol (HDL-C) (P < 0.05). In addition, the betatrophin had higher odds of having DN [odds ratio (OR) = 5.65, 95 % confidence interval (CI) 2.17–14.57, P < 0.001]. CONCLUSION: Betatrophin is significantly increased in T2DM patients with different stages of albuminuria. Betatrophin may be a novel endocrine regulator involved in DN development. BioMed Central 2016-01-07 /pmc/articles/PMC4704426/ /pubmed/26739836 http://dx.doi.org/10.1186/s12933-015-0326-9 Text en © Chen et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Investigation
Chen, Chang-Chiang
Susanto, Hendra
Chuang, Wen-Han
Liu, Ta-Yu
Wang, Chih-Hong
Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title_full Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title_fullStr Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title_full_unstemmed Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title_short Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
title_sort higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704426/
https://www.ncbi.nlm.nih.gov/pubmed/26739836
http://dx.doi.org/10.1186/s12933-015-0326-9
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