Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

BACKGROUND: Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that these DSBs during secondary antibody gene diversification are the primary source of...

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Detalles Bibliográficos
Autores principales: Chen, Zhangguo, Elos, Mihret T., Viboolsittiseri, Sawanee S., Gowan, Katherine, Leach, Sonia M., Rice, Michael, Eder, Maxwell D., Jones, Kenneth, Wang, Jing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704435/
https://www.ncbi.nlm.nih.gov/pubmed/26740101
http://dx.doi.org/10.1186/s13045-015-0230-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704435/
https://www.ncbi.nlm.nih.gov/pubmed/26740101
http://dx.doi.org/10.1186/s13045-015-0230-5

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