Cargando…

Combined deletion of Xrcc4 and Trp53 in mouse germinal center B cells leads to novel B cell lymphomas with clonal heterogeneity

BACKGROUND: Activated B lymphocytes harbor programmed DNA double-strand breaks (DSBs) initiated by activation-induced deaminase (AID) and repaired by non-homologous end-joining (NHEJ). While it has been proposed that these DSBs during secondary antibody gene diversification are the primary source of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Zhangguo, Elos, Mihret T., Viboolsittiseri, Sawanee S., Gowan, Katherine, Leach, Sonia M., Rice, Michael, Eder, Maxwell D., Jones, Kenneth, Wang, Jing H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704435/ https://www.ncbi.nlm.nih.gov/pubmed/26740101 http://dx.doi.org/10.1186/s13045-015-0230-5

Ejemplares similares

Unexpected effects of different genetic backgrounds on identification of genomic rearrangements via whole-genome next generation sequencing
por: Chen, Zhangguo, et al.
Publicado: (2016)

Clonal germinal center B cells function as a niche for T-cell lymphoma
por: Fujisawa, Manabu, et al.
Publicado: (2022)

Requirement of dendritic cells and B cells in the clonal deletion of Mls-reactive T cells in the thymus
Publicado: (1991)

The Trp53-Trp53inp1-Tnfrsf10b Pathway Regulates the Radiation Response of Mouse Spermatogonial Stem Cells
por: Ishii, Kei, et al.
Publicado: (2014)

Craniofacial Defects in Embryos with Homozygous Deletion of Eftud2 in Their Neural Crest Cells Are Not Rescued by Trp53 Deletion
por: Beauchamp, Marie-Claude, et al.
Publicado: (2022)

Distinct oncogenic phenotypes in hematopoietic specific deletions of Trp53
por: Palanichamy, Jayanth Kumar, et al.
Publicado: (2023)

Computer Simulation of Multi-Color Brainbow Staining and Clonal Evolution of B Cells in Germinal Centers
por: Meyer-Hermann, Michael, et al.
Publicado: (2018)

Restricted Clonality and Limited Germinal Center Reentry Characterize Memory B Cell Reactivation by Boosting
por: Mesin, Luka, et al.
Publicado: (2020)

Cyclin D3 Governs Clonal Expansion of Dark Zone Germinal Center B Cells
por: Ramezani-Rad, Parham, et al.
Publicado: (2020)

Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers
por: Castrillon, Carlos, et al.
Publicado: (2023)

Reappraisal of XRCC1 Arg194Trp polymorphism and glioma risk: a cumulative meta-analysis
por: Lu, Jun-Ti, et al.
Publicado: (2017)

Perinatal Blockade of B7-1 and B7-2 Inhibits Clonal Deletion of Highly Pathogenic Autoreactive T Cells
por: Gao, Jian-Xin, et al.
Publicado: (2002)

DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta-analysis
por: LI, WENYAN, et al.
Publicado: (2014)

Association of -77T>C and Arg194trp polymorphisms of XRCC1 with risk of coronary artery diseases in Iranian population
por: Pahlavanneshan, Saghar, et al.
Publicado: (2016)

Kaliziri extract upregulates tyrosinase, TRP-1, TRP-2 and MITF expression in murine B16 melanoma cells
por: Tuerxuntayi, Adila, et al.
Publicado: (2014)

Clonal redemption of B cells in cancer
por: McCaw, Tyler R., et al.
Publicado: (2023)

XRCC1 Arg194Trp polymorphism, risk of nonmelanoma skin cancer and extramammary Paget’s disease in a Japanese population
por: Chiyomaru, Koji, et al.
Publicado: (2012)

Association of XRCC1 Trp194 allele with risk of breast cancer, and Ki67 protein status in breast tumor tissues
por: Jalali, Chiya, et al.
Publicado: (2016)

Vaccination establishes clonal relatives of germinal center T cells in the blood of humans
por: Heit, Antje, et al.
Publicado: (2017)

Polymorphisms of Homologous Recombination RAD51, RAD51B, XRCC2, and XRCC3 Genes and the Risk of Prostate Cancer
por: Nowacka-Zawisza, Maria, et al.
Publicado: (2015)

Quantitative Impact of Thymic Clonal Deletion on the T Cell Repertoire
por: van Meerwijk, Joost P.M., et al.
Publicado: (1997)

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/–) and Trp53(−/−) mice
por: Krais, Annette M., et al.
Publicado: (2015)

Acquired Mls-1a-like clonal deletion in Mls-1b mice
Publicado: (1992)

Global Deletion of Trp53 Reverts Ovarian Tumor Phenotype of the Germ Cell–Deficient White Spotting Variant (Wv) Mice()
por: Cai, Kathy Qi, et al.
Publicado: (2015)

Deletion of Trp53 and Rb1 in Ctsk‐expressing cells drives osteosarcoma progression by activating glucose metabolism and YAP signaling
por: Li, Yang, et al.
Publicado: (2022)

Association of XRCC1, XRCC2 and XRCC3 Gene Polymorphism with Esophageal Cancer Risk
por: Kaur, Jagjeet, et al.
Publicado: (2020)

Clonal relationships in recurrent B-cell lymphomas
por: Lee, Seung Eun, et al.
Publicado: (2016)

Regulation of germinal center B‐cell differentiation
por: Zhang, Yang, et al.
Publicado: (2016)

B7/CD28 in Central Tolerance: Costimulation Promotes Maturation of Regulatory T Cell Precursors and Prevents Their Clonal Deletion
por: Hinterberger, Maria, et al.
Publicado: (2011)

Jdp2 downregulates Trp53 transcription to promote leukaemogenesis in the context of Trp53 heterozygosity
por: van der Weyden, L, et al.
Publicado: (2013)

The XRCC1 Arg194Trp polymorphism was associated with the risk of head and neck squamous cell carcinoma development: Results from a systematic review and meta‐analysis
por: Mohtasham, Nooshin, et al.
Publicado: (2022)

Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching
por: Wang, Jing H., et al.
Publicado: (2008)

Maintenance of pluripotency in mouse ES cells without Trp53
por: Shigeta, Masaki, et al.
Publicado: (2013)

No association between XRCC1 gene Arg194Trp polymorphism and risk of lung cancer: evidence based on an updated cumulative meta-analysis
por: Zhang, Jing, et al.
Publicado: (2014)

XRCC1 Arg399Gln and Arg194Trp Polymorphisms and Risk of Systemic Lupus Erythematosus in an Iranian Population: A Pilot Study
por: Salimi, Saeedeh, et al.
Publicado: (2014)

The XRCC1 Arg194Trp polymorphism is significantly associated with lung adenocarcinoma: a case-control study in an Eastern European Caucasian group
por: Cătană, Andreea, et al.
Publicado: (2015)

Catalytically impaired TrpA subunit of tryptophan synthase from Chlamydia trachomatis is an allosteric regulator of TrpB
por: Michalska, Karolina, et al.
Publicado: (2021)

A Meta-Analysis for Association of XRCC1, XRCC2 and XRCC3 Polymorphisms with Susceptibility to Thyroid Cancer
por: Mandegari, Mohammad, et al.
Publicado: (2021)

Liver-expressed Igκ superantigen induces tolerance of polyclonal B cells by clonal deletion not κ to λ receptor editing
por: Ota, Takayuki, et al.
Publicado: (2011)

Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Subtype of the Thyroid
por: Waqar, Syed Hamza Bin, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_9cuj8gjrmml1dhqf3fgihs1qpj