Oral administration of erythromycin decreases RNA toxicity in myotonic dystrophy

OBJECTIVE: Myotonic dystrophy type 1 (DM1) is caused by the expansion of a CTG repeat in the 3′ untranslated region of DMPK. The transcripts containing an expanded CUG repeat (CUG (exp)) result in a toxic gain‐of‐function by forming ribonuclear foci that sequester the alternative splicing factor mus...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakamori, Masayuki, Taylor, Katarzyna, Mochizuki, Hideki, Sobczak, Krzysztof, Takahashi, Masanori P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704483/
https://www.ncbi.nlm.nih.gov/pubmed/26783549
http://dx.doi.org/10.1002/acn3.271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704483/
https://www.ncbi.nlm.nih.gov/pubmed/26783549
http://dx.doi.org/10.1002/acn3.271

Ejemplares similares