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New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver
Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of ac...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704799/ https://www.ncbi.nlm.nih.gov/pubmed/26741814 http://dx.doi.org/10.1371/journal.pone.0146497 |
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author | Gulfo, Jose Ledda, Angelo Gea-Sorlí, Sabrina Bonjoch, Laia Closa, Daniel Grasa, Mar Esteve, Montserrat |
author_facet | Gulfo, Jose Ledda, Angelo Gea-Sorlí, Sabrina Bonjoch, Laia Closa, Daniel Grasa, Mar Esteve, Montserrat |
author_sort | Gulfo, Jose |
collection | PubMed |
description | Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of acute pancreatitis in cbg(-/-) mice we investigated whether changes in CBG affect the progression of the disease as well as the metabolism of glucocorticoids in the lung. Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels. In the lung, CBG expression and protein level were detected, and it is noteworthy that these showed a sexual dimorphism opposite to the liver, i.e. with higher levels in males. Reduced expression of 11β-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed. Our results indicate that, in addition to glucocorticoids transporter, CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung. |
format | Online Article Text |
id | pubmed-4704799 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47047992016-01-15 New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver Gulfo, Jose Ledda, Angelo Gea-Sorlí, Sabrina Bonjoch, Laia Closa, Daniel Grasa, Mar Esteve, Montserrat PLoS One Research Article Corticosteroid-binding globulin (CBG) is the specific plasma transport glycoprotein for glucocorticoids. Circulating CBG is mainly synthesized in liver but, its synthesis has been located also in other organs as placenta, kidney and adipose tissue with unknown role. Using an experimental model of acute pancreatitis in cbg(-/-) mice we investigated whether changes in CBG affect the progression of the disease as well as the metabolism of glucocorticoids in the lung. Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels. In the lung, CBG expression and protein level were detected, and it is noteworthy that these showed a sexual dimorphism opposite to the liver, i.e. with higher levels in males. Reduced expression of 11β-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed. Our results indicate that, in addition to glucocorticoids transporter, CBG is involved in the gender differences observed in corticosteroids circulating levels and plays a role in the local regulation of corticosteroids availability in organs like lung. Public Library of Science 2016-01-07 /pmc/articles/PMC4704799/ /pubmed/26741814 http://dx.doi.org/10.1371/journal.pone.0146497 Text en © 2016 Gulfo et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Gulfo, Jose Ledda, Angelo Gea-Sorlí, Sabrina Bonjoch, Laia Closa, Daniel Grasa, Mar Esteve, Montserrat New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title_full | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title_fullStr | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title_full_unstemmed | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title_short | New Roles for Corticosteroid Binding Globulin and Opposite Expression Profiles in Lung and Liver |
title_sort | new roles for corticosteroid binding globulin and opposite expression profiles in lung and liver |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704799/ https://www.ncbi.nlm.nih.gov/pubmed/26741814 http://dx.doi.org/10.1371/journal.pone.0146497 |
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