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Propranolol Targets Hemangioma Stem Cells via cAMP and Mitogen-Activated Protein Kinase Regulation
Infantile hemangiomas (IHs) are the most common vascular tumor and arise from a hemangioma stem cell (HemSC). Propranolol has proved efficacious for problematic IHs. Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist that can lower cAMP levels and activate the mitogen-activated pro...
Autores principales: | Munabi, Naikhoba C.O., England, Ryan W., Edwards, Andrew K., Kitajewski, Alison A., Tan, Qian Kun, Weinstein, Andrew, Kung, Justin E., Wilcox, Maya, Kitajewski, Jan K., Shawber, Carrie J., Wu, June K. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AlphaMed Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4704871/ https://www.ncbi.nlm.nih.gov/pubmed/26574555 http://dx.doi.org/10.5966/sctm.2015-0076 |
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