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Genetic screening reveals a link between Wnt signaling and antitubulin drugs

The antitubulin drugs, paclitaxel (PX) and colchicine (COL), inhibit cell growth and are therapeutically valuable. PX stabilizes microtubules, while COL promotes their depolymerization. But, the drug concentrations that alter tubulin polymerization are hundreds of times higher than their clinically...

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Detalles Bibliográficos
Autores principales:	Khan, A H, Bloom, J S, Faridmoayer, E, Smith, D J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705004/ https://www.ncbi.nlm.nih.gov/pubmed/26149735 http://dx.doi.org/10.1038/tpj.2015.50

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