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Oxygen Availability for Porphyrin Biosynthesis Enzymes Determines the Production of Protoporphyrin IX (PpIX) during Hypoxia

5-Aminolevulinic acid (ALA), a precursor of porphyrin, is specifically converted to the fluorescent substance protoporphyrin IX (PpIX) in tumors to be used as a prodrug for photodynamic therapy and diagnosis. Hypoxia, a common feature of solid tumors, decreases the efficacy of ALA-based photodynamic...

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Detalles Bibliográficos
Autores principales:	Otsuka, Shimpei, Matsumoto, Kentaro, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705112/ https://www.ncbi.nlm.nih.gov/pubmed/26717566 http://dx.doi.org/10.1371/journal.pone.0146026

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