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Influence of HLA-DR and -DQ alleles on autoantibody recognition of distinct epitopes within the juxtamembrane domain of the IA-2 autoantigen in type 1 diabetes

AIMS/HYPOTHESIS: Insulinoma-associated protein 2 (IA-2) is a major target of autoimmunity in type 1 diabetes. When first detected, IA-2-autoantibodies commonly bind epitopes in the juxtamembrane (JM) domain of IA-2 and antibody responses subsequently spread to the tyrosine phosphatase domain. Defini...

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Detalles Bibliográficos
Autores principales:	Richardson, Carolyn C., McLaughlin, Kerry A., Morgan, Diana, Feltbower, Richard G., Christie, Michael R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705114/ https://www.ncbi.nlm.nih.gov/pubmed/26564179 http://dx.doi.org/10.1007/s00125-015-3803-5

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