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Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk
A spermatic granuloma is a chronic inflammatory reaction produced in response to extravasated sperm within the intertubular connective tissue. The present study investigates the possible toxic effects of water extract of Heliotropium bacciferum on the reproductive system of male albino rats and the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705245/ https://www.ncbi.nlm.nih.gov/pubmed/26858543 http://dx.doi.org/10.1016/j.sjbs.2015.09.008 |
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author | Alanazi, Khalid Alahmadi, Bassam A. Alhimaidi, Ahmed Abou-Tarboush, Faisal M. Farah, Mohammad Abul Mahmoud, Ahmed Alfaifi, Mohamed |
author_facet | Alanazi, Khalid Alahmadi, Bassam A. Alhimaidi, Ahmed Abou-Tarboush, Faisal M. Farah, Mohammad Abul Mahmoud, Ahmed Alfaifi, Mohamed |
author_sort | Alanazi, Khalid |
collection | PubMed |
description | A spermatic granuloma is a chronic inflammatory reaction produced in response to extravasated sperm within the intertubular connective tissue. The present study investigates the possible toxic effects of water extract of Heliotropium bacciferum on the reproductive system of male albino rats and the associated potential for the development of spermatic granulomas. H. bacciferum is a herbal plant used in traditional medicine and reported to have cytotoxic effects due to pyrrolizidine alkaloids. Histological examinations revealed no changes in the tissues of the testes, although, some changes were detected in the cauda epididymis, the most important of which was the development of small lesions of spermatic granulomas. Clear gaps were observed between the epithelial linings of the epididymal tubules. |
format | Online Article Text |
id | pubmed-4705245 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-47052452016-02-08 Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk Alanazi, Khalid Alahmadi, Bassam A. Alhimaidi, Ahmed Abou-Tarboush, Faisal M. Farah, Mohammad Abul Mahmoud, Ahmed Alfaifi, Mohamed Saudi J Biol Sci Original Article A spermatic granuloma is a chronic inflammatory reaction produced in response to extravasated sperm within the intertubular connective tissue. The present study investigates the possible toxic effects of water extract of Heliotropium bacciferum on the reproductive system of male albino rats and the associated potential for the development of spermatic granulomas. H. bacciferum is a herbal plant used in traditional medicine and reported to have cytotoxic effects due to pyrrolizidine alkaloids. Histological examinations revealed no changes in the tissues of the testes, although, some changes were detected in the cauda epididymis, the most important of which was the development of small lesions of spermatic granulomas. Clear gaps were observed between the epithelial linings of the epididymal tubules. Elsevier 2016-01 2015-10-24 /pmc/articles/PMC4705245/ /pubmed/26858543 http://dx.doi.org/10.1016/j.sjbs.2015.09.008 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Alanazi, Khalid Alahmadi, Bassam A. Alhimaidi, Ahmed Abou-Tarboush, Faisal M. Farah, Mohammad Abul Mahmoud, Ahmed Alfaifi, Mohamed Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title | Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title_full | Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title_fullStr | Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title_full_unstemmed | Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title_short | Development of spermatic granuloma in albino rats following administration of water extract of Heliotropium bacciferum Forssk |
title_sort | development of spermatic granuloma in albino rats following administration of water extract of heliotropium bacciferum forssk |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705245/ https://www.ncbi.nlm.nih.gov/pubmed/26858543 http://dx.doi.org/10.1016/j.sjbs.2015.09.008 |
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