β-Secretase 1’s Targeting Reduces Hyperphosphorilated Tau, Implying Autophagy Actors in 3xTg-AD Mice

β-site APP cleaving enzyme 1 (BACE1) initiates APP cleavage, which has been reported to be an inducer of tau pathology by altering proteasome functions in Alzheimer’s disease (AD). However, the exact relationship between BACE1 and PHF (Paired Helical Filaments) formation is not clear. In this study,...

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Detalles Bibliográficos
Autores principales: Piedrahita, Diego, Castro-Alvarez, John Fredy, Boudreau, Ryan L., Villegas-Lanau, Andres, Kosik, Kenneth S., Gallego-Gomez, Juan Carlos, Cardona-Gómez, Gloria Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705306/
https://www.ncbi.nlm.nih.gov/pubmed/26778963
http://dx.doi.org/10.3389/fncel.2015.00498

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705306/
https://www.ncbi.nlm.nih.gov/pubmed/26778963
http://dx.doi.org/10.3389/fncel.2015.00498

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