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Structure of UBE2Z Enzyme Provides Functional Insight into Specificity in the FAT10 Protein Conjugation Machinery

FAT10 conjugation, a post-translational modification analogous to ubiquitination, specifically requires UBA6 and UBE2Z as its activating (E1) and conjugating (E2) enzymes. Interestingly, these enzymes can also function in ubiquitination. We have determined the crystal structure of UBE2Z and report h...

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Detalles Bibliográficos
Autores principales:	Schelpe, Julien, Monté, Didier, Dewitte, Frédérique, Sixma, Titia K., Rucktooa, Prakash
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Protein Structure and Folding
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705383/ https://www.ncbi.nlm.nih.gov/pubmed/26555268 http://dx.doi.org/10.1074/jbc.M115.671545

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