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Impact of PTEN abnormalities on outcome in pediatric patients with T-cell acute lymphoblastic leukemia treated on the MRC UKALL2003 trial

PTEN gene inactivation by mutation or deletion is common in pediatric T-cell acute lymphoblastic leukemia (T-ALL), but the impact on outcome is unclear, particularly in patients with NOTCH1/FBXW7 mutations. We screened samples from 145 patients treated on the MRC UKALL2003 trial for PTEN mutations u...

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Detalles Bibliográficos
Autores principales:	Jenkinson, S, Kirkwood, A A, Goulden, N, Vora, A, Linch, D C, Gale, R E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705426/ https://www.ncbi.nlm.nih.gov/pubmed/26220040 http://dx.doi.org/10.1038/leu.2015.206

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