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Whole exome sequencing identifies novel candidate genes that modify chronic obstructive pulmonary disease susceptibility

BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by an irreversible airflow limitation in response to inhalation of noxious stimuli, such as cigarette smoke. However, only 15–20 % smokers manifest COPD, suggesting a role for genetic predisposition. Although genome-wide assoc...

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Detalles Bibliográficos
Autores principales:	Bruse, Shannon, Moreau, Michael, Bromberg, Yana, Jang, Jun-Ho, Wang, Nan, Ha, Hongseok, Picchi, Maria, Lin, Yong, Langley, Raymond J., Qualls, Clifford, Klensney-Tait, Julia, Zabner, Joseph, Leng, Shuguang, Mao, Jenny, Belinsky, Steven A., Xing, Jinchuan, Nyunoya, Toru
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Primary Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705629/ https://www.ncbi.nlm.nih.gov/pubmed/26744305 http://dx.doi.org/10.1186/s40246-015-0058-7

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