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A human transcription factor in search mode

Transcription factors (TF) can change shape to bind and recognize DNA, shifting the energy landscape from a weak binding, rapid search mode to a higher affinity recognition mode. However, the mechanism(s) driving this conformational change remains unresolved and in most cases high-resolution structu...

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Detalles Bibliográficos
Autores principales:	Hauser, Kevin, Essuman, Bernard, He, Yiqing, Coutsias, Evangelos, Garcia-Diaz, Miguel, Simmerling, Carlos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Computational Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705650/ https://www.ncbi.nlm.nih.gov/pubmed/26673724 http://dx.doi.org/10.1093/nar/gkv1091

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