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Probing the reactivity of singlet oxygen with purines

The reaction of singlet molecular oxygen with purine DNA bases is investigated by computational means. We support the formation of a transient endoperoxide for guanine and by classical molecular dynamics simulations we demonstrate that the formation of this adduct does not affect the B-helicity. We...

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Detalles Bibliográficos
Autores principales:	Dumont, Elise, Grüber, Raymond, Bignon, Emmanuelle, Morell, Christophe, Moreau, Yohann, Monari, Antonio, Ravanat, Jean-Luc
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705671/ https://www.ncbi.nlm.nih.gov/pubmed/26656495 http://dx.doi.org/10.1093/nar/gkv1364

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