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Quantification of DNA cleavage specificity in Hi-C experiments

Hi-C experiments produce large numbers of DNA sequence read pairs that are typically analyzed to deduce genomewide interactions between arbitrary loci. A key step in these experiments is the cleavage of cross-linked chromatin with a restriction endonuclease. Although this cleavage should happen spec...

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Detalles Bibliográficos
Autores principales: Meluzzi, Dario, Arya, Gaurav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705682/
https://www.ncbi.nlm.nih.gov/pubmed/26264668
http://dx.doi.org/10.1093/nar/gkv820