Epigenetic factor EPC1 is a master regulator of DNA damage response by interacting with E2F1 to silence death and activate metastasis-related gene signatures

Transcription factor E2F1 is a key regulator of cell proliferation and apoptosis. Recently, it has been shown that aberrant E2F1 expression often detectable in advanced cancers contributes essentially to cancer cell propagation and characterizes the aggressive potential of a tumor. Conceptually, thi...

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Detalles Bibliográficos
Autores principales: Wang, Yajie, Alla, Vijay, Goody, Deborah, Gupta, Shailendra K., Spitschak, Alf, Wolkenhauer, Olaf, Pützer, Brigitte M., Engelmann, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705687/
https://www.ncbi.nlm.nih.gov/pubmed/26350215
http://dx.doi.org/10.1093/nar/gkv885

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