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The p53-p21-DREAM-CDE/CHR pathway regulates G(2)/M cell cycle genes

The tumor suppressor p53 functions predominantly as a transcription factor by activating and downregulating gene expression, leading to cell cycle arrest or apoptosis. p53 was shown to indirectly repress transcription of the CCNB2, KIF23 and PLK4 cell cycle genes through the recently discovered p53-...

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Detalles Bibliográficos
Autores principales:	Fischer, Martin, Quaas, Marianne, Steiner, Lydia, Engeland, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2016
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705690/ https://www.ncbi.nlm.nih.gov/pubmed/26384566 http://dx.doi.org/10.1093/nar/gkv927

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