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Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy

BACKGROUND: Influenza is a major public health issue worldwide. It is characterized by episodes of infection that involve hundreds of millions of people each year. Since that in the seasons 2010–2011 and 2011–2012 the circulation of FLUB was decreasing we evaluated the clinical presentation, demogra...

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Autores principales: Mancinelli, Livia, Onori, Manuela, Concato, Carlo, Sorge, Roberto, Chiavelli, Stefano, Coltella, Luana, Raucci, Umberto, Reale, Antonio, Menichella, Donato, Russo, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705698/
https://www.ncbi.nlm.nih.gov/pubmed/26743673
http://dx.doi.org/10.1186/s12879-015-1333-x
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author Mancinelli, Livia
Onori, Manuela
Concato, Carlo
Sorge, Roberto
Chiavelli, Stefano
Coltella, Luana
Raucci, Umberto
Reale, Antonio
Menichella, Donato
Russo, Cristina
author_facet Mancinelli, Livia
Onori, Manuela
Concato, Carlo
Sorge, Roberto
Chiavelli, Stefano
Coltella, Luana
Raucci, Umberto
Reale, Antonio
Menichella, Donato
Russo, Cristina
author_sort Mancinelli, Livia
collection PubMed
description BACKGROUND: Influenza is a major public health issue worldwide. It is characterized by episodes of infection that involve hundreds of millions of people each year. Since that in the seasons 2010–2011 and 2011–2012 the circulation of FLUB was decreasing we evaluated the clinical presentation, demographic characteristics, admitting department, and length of stay in children who contracted influenza admitted to Bambino Gesù Children’s Hospital, during the 2012–2013 influenza season, with the aim to establish if the recover of FLUB was associated to a clinical worsening, in comparison with those due to FLUA. METHODS: A total of 133 respiratory specimens, collected from patients with symptoms of respiratory tract infections, positive for the Influenza A and B viruses (FLUA and B) were subtyped. Comparisons between the FLUA and FLUB groups were performed with the one-way ANOVA for continuous parametric variables, the Mann-Whitney test for non-parametric variables, or the Chi-Square test or Fisher’s exact test (if cells <5) for categorical variables. RESULTS: 87.09 % of the FLUA isolates were the H1N1 subtype and 12.90 % were H3N2. Among the FLUB isolates, 91.54 % were the B/Yamagata/16/88 lineage and 8.45 % were the B/Victoria/02/87 lineage. The largest number of FLUA/H1N1 cases was observed in children less than 1 years old, while the B/Yamagata/16/88 lineage was most prevalent in children 3–6 years old. Fever was a common symptom for both FLUA and B affected patients. However, respiratory symptoms were more prevalent in patients affected by FLUA. The median length of stay in the hospital was 5 days for FLUA and 3 days for FLUB. CONCLUSIONS: The clinical features correlated to different Influenza viruses, and relevant subtypes, were evaluated concluding that the increasing of FLUB in the season 2012–2013 was without any dramatic change in clinical manifestation. Our findings suggest, finally, that a stronger commitment to managing patients affected by FLUA is required, as the disease is more severe than FLUB.
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spelling pubmed-47056982016-01-09 Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy Mancinelli, Livia Onori, Manuela Concato, Carlo Sorge, Roberto Chiavelli, Stefano Coltella, Luana Raucci, Umberto Reale, Antonio Menichella, Donato Russo, Cristina BMC Infect Dis Research Article BACKGROUND: Influenza is a major public health issue worldwide. It is characterized by episodes of infection that involve hundreds of millions of people each year. Since that in the seasons 2010–2011 and 2011–2012 the circulation of FLUB was decreasing we evaluated the clinical presentation, demographic characteristics, admitting department, and length of stay in children who contracted influenza admitted to Bambino Gesù Children’s Hospital, during the 2012–2013 influenza season, with the aim to establish if the recover of FLUB was associated to a clinical worsening, in comparison with those due to FLUA. METHODS: A total of 133 respiratory specimens, collected from patients with symptoms of respiratory tract infections, positive for the Influenza A and B viruses (FLUA and B) were subtyped. Comparisons between the FLUA and FLUB groups were performed with the one-way ANOVA for continuous parametric variables, the Mann-Whitney test for non-parametric variables, or the Chi-Square test or Fisher’s exact test (if cells <5) for categorical variables. RESULTS: 87.09 % of the FLUA isolates were the H1N1 subtype and 12.90 % were H3N2. Among the FLUB isolates, 91.54 % were the B/Yamagata/16/88 lineage and 8.45 % were the B/Victoria/02/87 lineage. The largest number of FLUA/H1N1 cases was observed in children less than 1 years old, while the B/Yamagata/16/88 lineage was most prevalent in children 3–6 years old. Fever was a common symptom for both FLUA and B affected patients. However, respiratory symptoms were more prevalent in patients affected by FLUA. The median length of stay in the hospital was 5 days for FLUA and 3 days for FLUB. CONCLUSIONS: The clinical features correlated to different Influenza viruses, and relevant subtypes, were evaluated concluding that the increasing of FLUB in the season 2012–2013 was without any dramatic change in clinical manifestation. Our findings suggest, finally, that a stronger commitment to managing patients affected by FLUA is required, as the disease is more severe than FLUB. BioMed Central 2016-01-08 /pmc/articles/PMC4705698/ /pubmed/26743673 http://dx.doi.org/10.1186/s12879-015-1333-x Text en © Mancinelli et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Mancinelli, Livia
Onori, Manuela
Concato, Carlo
Sorge, Roberto
Chiavelli, Stefano
Coltella, Luana
Raucci, Umberto
Reale, Antonio
Menichella, Donato
Russo, Cristina
Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title_full Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title_fullStr Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title_full_unstemmed Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title_short Clinical features of children hospitalized with influenza A and B infections during the 2012–2013 influenza season in Italy
title_sort clinical features of children hospitalized with influenza a and b infections during the 2012–2013 influenza season in italy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705698/
https://www.ncbi.nlm.nih.gov/pubmed/26743673
http://dx.doi.org/10.1186/s12879-015-1333-x
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