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Factors influencing the spinal motoneurons in development
The development of the spinal cord needs a concerted interaction of transcription factors activating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventra...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705789/ https://www.ncbi.nlm.nih.gov/pubmed/26807112 http://dx.doi.org/10.4103/1673-5374.169639 |
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author | Wiese, Stefan |
author_facet | Wiese, Stefan |
author_sort | Wiese, Stefan |
collection | PubMed |
description | The development of the spinal cord needs a concerted interaction of transcription factors activating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventral axis. Additionally the axons of the motoneurons have to cross the central nervous system barrier to connect to the periphery. Intensive anatomical studies have been followed by molecular characterization of the different subsets of transcription factors that are expressed by cells of the developing spinal cord. Here, intensive studies for the most important appearing cells, the motoneurons, have resulted in a good knowledge on the expression patterns of these proteins. Nonetheless motoneurons are by far not the only important cells and the concert activity of all cells besides them is necessary for the correct function and integrity of motoneurons within the spinal cord. This article will briefly summarize the different aspects on spinal cord development and focuses on the differentiation as well as the functionalization of motoneurons. |
format | Online Article Text |
id | pubmed-4705789 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47057892016-01-22 Factors influencing the spinal motoneurons in development Wiese, Stefan Neural Regen Res Invited Review The development of the spinal cord needs a concerted interaction of transcription factors activating diverse genes and signals from outside acting on the specification of the different cells. Signals have to act on the segments of the embryo as well as on the cranial-caudal axis and the dorso-ventral axis. Additionally the axons of the motoneurons have to cross the central nervous system barrier to connect to the periphery. Intensive anatomical studies have been followed by molecular characterization of the different subsets of transcription factors that are expressed by cells of the developing spinal cord. Here, intensive studies for the most important appearing cells, the motoneurons, have resulted in a good knowledge on the expression patterns of these proteins. Nonetheless motoneurons are by far not the only important cells and the concert activity of all cells besides them is necessary for the correct function and integrity of motoneurons within the spinal cord. This article will briefly summarize the different aspects on spinal cord development and focuses on the differentiation as well as the functionalization of motoneurons. Medknow Publications & Media Pvt Ltd 2015-11 /pmc/articles/PMC4705789/ /pubmed/26807112 http://dx.doi.org/10.4103/1673-5374.169639 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Invited Review Wiese, Stefan Factors influencing the spinal motoneurons in development |
title | Factors influencing the spinal motoneurons in development |
title_full | Factors influencing the spinal motoneurons in development |
title_fullStr | Factors influencing the spinal motoneurons in development |
title_full_unstemmed | Factors influencing the spinal motoneurons in development |
title_short | Factors influencing the spinal motoneurons in development |
title_sort | factors influencing the spinal motoneurons in development |
topic | Invited Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705789/ https://www.ncbi.nlm.nih.gov/pubmed/26807112 http://dx.doi.org/10.4103/1673-5374.169639 |
work_keys_str_mv | AT wiesestefan factorsinfluencingthespinalmotoneuronsindevelopment |