Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?

The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats...

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Autores principales: Sahin, Murat, Gullu, Huriye, Peker, Kemal, Sayar, Ilyas, Binici, Orhan, Yildiz, Huseyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705796/
https://www.ncbi.nlm.nih.gov/pubmed/26807119
http://dx.doi.org/10.4103/1673-5374.170312
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author Sahin, Murat
Gullu, Huriye
Peker, Kemal
Sayar, Ilyas
Binici, Orhan
Yildiz, Huseyin
author_facet Sahin, Murat
Gullu, Huriye
Peker, Kemal
Sayar, Ilyas
Binici, Orhan
Yildiz, Huseyin
author_sort Sahin, Murat
collection PubMed
description The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia.
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spelling pubmed-47057962016-01-22 Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia? Sahin, Murat Gullu, Huriye Peker, Kemal Sayar, Ilyas Binici, Orhan Yildiz, Huseyin Neural Regen Res Research Article The neuroprotective effects of propofol have been confirmed. However, it remains unclear whether intrathecal administration of propofol exhibits neuroprotective effects on spinal cord ischemia. At 1 hour prior to spinal cord ischemia, propofol (100 and 300 µg) was intrathecally administered in rats with spinal cord ischemia. Propofol pre-treatment greatly improved rat pathological changes and neurological function deficits at 24 hours after spinal cord ischemia. These results suggest that intrathecal administration of propofol exhibits neuroprotective effects on spinal cord structural and functional damage caused by ischemia. Medknow Publications & Media Pvt Ltd 2015-11 /pmc/articles/PMC4705796/ /pubmed/26807119 http://dx.doi.org/10.4103/1673-5374.170312 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Research Article
Sahin, Murat
Gullu, Huriye
Peker, Kemal
Sayar, Ilyas
Binici, Orhan
Yildiz, Huseyin
Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title_full Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title_fullStr Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title_full_unstemmed Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title_short Does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
title_sort does the intrathecal propofol have a neuroprotective effect on spinal cord ischemia?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705796/
https://www.ncbi.nlm.nih.gov/pubmed/26807119
http://dx.doi.org/10.4103/1673-5374.170312
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