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Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke
Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression of specific ion transporters and receptors, a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705808/ https://www.ncbi.nlm.nih.gov/pubmed/26807131 http://dx.doi.org/10.4103/1673-5374.170324 |
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author | Yu, Qi-jin Tao, Hong Wang, Xin Li, Ming-chang |
author_facet | Yu, Qi-jin Tao, Hong Wang, Xin Li, Ming-chang |
author_sort | Yu, Qi-jin |
collection | PubMed |
description | Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression of specific ion transporters and receptors, and contain fewer fenestrations and pinocytotic vesicles. Brain microvascular endothelial cells also synthesize several factors that influence blood vessel function. This review describes the morphological characteristics and functions of brain microvascular endothelial cells, and summarizes current knowledge regarding changes in brain microvascular endothelial cells during stroke progression and therapies. Future studies should focus on identifying mechanisms underlying such changes and developing possible neuroprotective therapeutic interventions. |
format | Online Article Text |
id | pubmed-4705808 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-47058082016-01-22 Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke Yu, Qi-jin Tao, Hong Wang, Xin Li, Ming-chang Neural Regen Res Review Brain microvascular endothelial cells form the interface between nervous tissue and circulating blood, and regulate central nervous system homeostasis. Brain microvascular endothelial cells differ from peripheral endothelial cells with regards expression of specific ion transporters and receptors, and contain fewer fenestrations and pinocytotic vesicles. Brain microvascular endothelial cells also synthesize several factors that influence blood vessel function. This review describes the morphological characteristics and functions of brain microvascular endothelial cells, and summarizes current knowledge regarding changes in brain microvascular endothelial cells during stroke progression and therapies. Future studies should focus on identifying mechanisms underlying such changes and developing possible neuroprotective therapeutic interventions. Medknow Publications & Media Pvt Ltd 2015-11 /pmc/articles/PMC4705808/ /pubmed/26807131 http://dx.doi.org/10.4103/1673-5374.170324 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Yu, Qi-jin Tao, Hong Wang, Xin Li, Ming-chang Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title | Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title_full | Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title_fullStr | Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title_full_unstemmed | Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title_short | Targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
title_sort | targeting brain microvascular endothelial cells: a therapeutic approach to neuroprotection against stroke |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705808/ https://www.ncbi.nlm.nih.gov/pubmed/26807131 http://dx.doi.org/10.4103/1673-5374.170324 |
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