The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system

The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors th...

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Detalles Bibliográficos
Autores principales: Liu, Jing, Gao, Hong-yan, Wang, Xiao-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705809/
https://www.ncbi.nlm.nih.gov/pubmed/26807132
http://dx.doi.org/10.4103/1673-5374.170325
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author Liu, Jing
Gao, Hong-yan
Wang, Xiao-feng
author_facet Liu, Jing
Gao, Hong-yan
Wang, Xiao-feng
author_sort Liu, Jing
collection PubMed
description The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore, a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system.
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spelling pubmed-47058092016-01-22 The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system Liu, Jing Gao, Hong-yan Wang, Xiao-feng Neural Regen Res Review The Rho/Rho-associated coiled-coil containing protein kinase (Rho/ROCK) pathway is a major signaling pathway in the central nervous system, transducing inhibitory signals to block regeneration. After central nervous system damage, the main cause of impaired regeneration is the presence of factors that strongly inhibit regeneration in the surrounding microenvironment. These factors signal through the Rho/ROCK signaling pathway to inhibit regeneration. Therefore, a thorough understanding of the Rho/ROCK signaling pathway is crucial for advancing studies on regeneration and repair of the injured central nervous system. Medknow Publications & Media Pvt Ltd 2015-11 /pmc/articles/PMC4705809/ /pubmed/26807132 http://dx.doi.org/10.4103/1673-5374.170325 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review
Liu, Jing
Gao, Hong-yan
Wang, Xiao-feng
The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title_full The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title_fullStr The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title_full_unstemmed The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title_short The role of the Rho/ROCK signaling pathway in inhibiting axonal regeneration in the central nervous system
title_sort role of the rho/rock signaling pathway in inhibiting axonal regeneration in the central nervous system
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705809/
https://www.ncbi.nlm.nih.gov/pubmed/26807132
http://dx.doi.org/10.4103/1673-5374.170325
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