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Phase I trial of EpCAM-targeting immunotoxin MOC31PE, alone and in combination with cyclosporin

BACKGROUND: A phase I trial was performed to determine the maximum tolerated dose (MTD), safety, pharmacokinetics and immunogenicity of the anti-EpCAM immunotoxin (IT) MOC31PE in cancer patients. An important part of the study was to investigate whether the addition of Sandimmune (cyclosporin, CsA)...

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Detalles Bibliográficos
Autores principales:	Andersson, Y, Engebraaten, O, Juell, S, Aamdal, S, Brunsvig, P, Fodstad, Ø, Dueland, S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705890/ https://www.ncbi.nlm.nih.gov/pubmed/26554649 http://dx.doi.org/10.1038/bjc.2015.380

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