Mapping the Binding Site of the Inhibitor Tariquidar That Stabilizes the First Transmembrane Domain of P-glycoprotein

ABC (ATP-binding cassette) transporters are clinically important because drug pumps like P-glycoprotein (P-gp, ABCB1) confer multidrug resistance and mutant ABC proteins are responsible for many protein-folding diseases such as cystic fibrosis. Identification of the tariquidar-binding site has been...

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Detalles Bibliográficos
Autores principales: Loo, Tip W., Clarke, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705942/
https://www.ncbi.nlm.nih.gov/pubmed/26507655
http://dx.doi.org/10.1074/jbc.M115.695171

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705942/
https://www.ncbi.nlm.nih.gov/pubmed/26507655
http://dx.doi.org/10.1074/jbc.M115.695171

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