Fasting and Systemic Insulin Signaling Regulate Phosphorylation of Brain Proteins That Modulate Cell Morphology and Link to Neurological Disorders

Diabetes is strongly associated with cognitive decline, but the molecular reasons are unknown. We found that fasting and peripheral insulin promote phosphorylation and dephosphorylation, respectively, of specific residues on brain proteins including cytoskeletal regulators such as slit-robo GTPase-a...

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Detalles Bibliográficos
Autores principales: Li, Min, Quan, Chao, Toth, Rachel, Campbell, David G., MacKintosh, Carol, Wang, Hong Yu, Chen, Shuai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2015
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705965/
https://www.ncbi.nlm.nih.gov/pubmed/26499801
http://dx.doi.org/10.1074/jbc.M115.668103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4705965/
https://www.ncbi.nlm.nih.gov/pubmed/26499801
http://dx.doi.org/10.1074/jbc.M115.668103

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