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Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration
Zinc finger motifs are distributed amongst many eukaryotic protein families, directing nucleic acid–protein and protein–protein interactions. Zinc finger protein 106 (ZFP106) has previously been associated with roles in immune response, muscle differentiation, testes development and DNA damage, alth...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706115/ https://www.ncbi.nlm.nih.gov/pubmed/26604141 http://dx.doi.org/10.1093/hmg/ddv471 |
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author | Joyce, Peter I. Fratta, Pietro Landman, Allison S. Mcgoldrick, Philip Wackerhage, Henning Groves, Michael Busam, Bharani Shiva Galino, Jorge Corrochano, Silvia Beskina, Olga A. Esapa, Christopher Ryder, Edward Carter, Sarah Stewart, Michelle Codner, Gemma Hilton, Helen Teboul, Lydia Tucker, Jennifer Lionikas, Arimantas Estabel, Jeanne Ramirez-Solis, Ramiro White, Jacqueline K. Brandner, Sebastian Plagnol, Vincent Bennet, David L. H. Abramov, Andrey Y. Greensmith, Linda Fisher, Elizabeth M. C. Acevedo-Arozena, Abraham |
author_facet | Joyce, Peter I. Fratta, Pietro Landman, Allison S. Mcgoldrick, Philip Wackerhage, Henning Groves, Michael Busam, Bharani Shiva Galino, Jorge Corrochano, Silvia Beskina, Olga A. Esapa, Christopher Ryder, Edward Carter, Sarah Stewart, Michelle Codner, Gemma Hilton, Helen Teboul, Lydia Tucker, Jennifer Lionikas, Arimantas Estabel, Jeanne Ramirez-Solis, Ramiro White, Jacqueline K. Brandner, Sebastian Plagnol, Vincent Bennet, David L. H. Abramov, Andrey Y. Greensmith, Linda Fisher, Elizabeth M. C. Acevedo-Arozena, Abraham |
author_sort | Joyce, Peter I. |
collection | PubMed |
description | Zinc finger motifs are distributed amongst many eukaryotic protein families, directing nucleic acid–protein and protein–protein interactions. Zinc finger protein 106 (ZFP106) has previously been associated with roles in immune response, muscle differentiation, testes development and DNA damage, although little is known about its specific function. To further investigate the function of ZFP106, we performed an in-depth characterization of Zfp106 deficient mice (Zfp106(−/−)), and we report a novel role for ZFP106 in motor and sensory neuronal maintenance and survival. Zfp106(−/−) mice develop severe motor abnormalities, major deficits in muscle strength and histopathological changes in muscle. Intriguingly, despite being highly expressed throughout the central nervous system, Zfp106(−/−) mice undergo selective motor and sensory neuronal and axonal degeneration specific to the spinal cord and peripheral nervous system. Neurodegeneration does not occur during development of Zfp106(−/−) mice, suggesting that ZFP106 is likely required for the maintenance of mature peripheral motor and sensory neurons. Analysis of embryonic Zfp106(−/−) motor neurons revealed deficits in mitochondrial function, with an inhibition of Complex I within the mitochondrial electron transport chain. Our results highlight a vital role for ZFP106 in sensory and motor neuron maintenance and reveal a novel player in mitochondrial dysfunction and neurodegeneration. |
format | Online Article Text |
id | pubmed-4706115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-47061152016-01-11 Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration Joyce, Peter I. Fratta, Pietro Landman, Allison S. Mcgoldrick, Philip Wackerhage, Henning Groves, Michael Busam, Bharani Shiva Galino, Jorge Corrochano, Silvia Beskina, Olga A. Esapa, Christopher Ryder, Edward Carter, Sarah Stewart, Michelle Codner, Gemma Hilton, Helen Teboul, Lydia Tucker, Jennifer Lionikas, Arimantas Estabel, Jeanne Ramirez-Solis, Ramiro White, Jacqueline K. Brandner, Sebastian Plagnol, Vincent Bennet, David L. H. Abramov, Andrey Y. Greensmith, Linda Fisher, Elizabeth M. C. Acevedo-Arozena, Abraham Hum Mol Genet Articles Zinc finger motifs are distributed amongst many eukaryotic protein families, directing nucleic acid–protein and protein–protein interactions. Zinc finger protein 106 (ZFP106) has previously been associated with roles in immune response, muscle differentiation, testes development and DNA damage, although little is known about its specific function. To further investigate the function of ZFP106, we performed an in-depth characterization of Zfp106 deficient mice (Zfp106(−/−)), and we report a novel role for ZFP106 in motor and sensory neuronal maintenance and survival. Zfp106(−/−) mice develop severe motor abnormalities, major deficits in muscle strength and histopathological changes in muscle. Intriguingly, despite being highly expressed throughout the central nervous system, Zfp106(−/−) mice undergo selective motor and sensory neuronal and axonal degeneration specific to the spinal cord and peripheral nervous system. Neurodegeneration does not occur during development of Zfp106(−/−) mice, suggesting that ZFP106 is likely required for the maintenance of mature peripheral motor and sensory neurons. Analysis of embryonic Zfp106(−/−) motor neurons revealed deficits in mitochondrial function, with an inhibition of Complex I within the mitochondrial electron transport chain. Our results highlight a vital role for ZFP106 in sensory and motor neuron maintenance and reveal a novel player in mitochondrial dysfunction and neurodegeneration. Oxford University Press 2016-01-15 2015-11-24 /pmc/articles/PMC4706115/ /pubmed/26604141 http://dx.doi.org/10.1093/hmg/ddv471 Text en © The Author 2015. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Joyce, Peter I. Fratta, Pietro Landman, Allison S. Mcgoldrick, Philip Wackerhage, Henning Groves, Michael Busam, Bharani Shiva Galino, Jorge Corrochano, Silvia Beskina, Olga A. Esapa, Christopher Ryder, Edward Carter, Sarah Stewart, Michelle Codner, Gemma Hilton, Helen Teboul, Lydia Tucker, Jennifer Lionikas, Arimantas Estabel, Jeanne Ramirez-Solis, Ramiro White, Jacqueline K. Brandner, Sebastian Plagnol, Vincent Bennet, David L. H. Abramov, Andrey Y. Greensmith, Linda Fisher, Elizabeth M. C. Acevedo-Arozena, Abraham Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title | Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title_full | Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title_fullStr | Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title_full_unstemmed | Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title_short | Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration |
title_sort | deficiency of the zinc finger protein zfp106 causes motor and sensory neurodegeneration |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706115/ https://www.ncbi.nlm.nih.gov/pubmed/26604141 http://dx.doi.org/10.1093/hmg/ddv471 |
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