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Intrahippocampal glucocorticoids generated by 11β-HSD1 affect memory in aged mice

11Beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) locally amplifies active glucocorticoids within specific tissues including in brain. In the hippocampus, 11β-HSD1 messenger RNA increases with aging. Here, we report significantly greater increases in intrahippocampal corticosterone (CORT) levels...

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Detalles Bibliográficos
Autores principales:	Yau, Joyce L.W., Wheelan, Nicola, Noble, June, Walker, Brian R., Webster, Scott P., Kenyon, Christopher J., Ludwig, Mike, Seckl, Jonathan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706164/ https://www.ncbi.nlm.nih.gov/pubmed/25109766 http://dx.doi.org/10.1016/j.neurobiolaging.2014.07.007

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