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A Higher Activation Threshold of Memory CD8(+) T Cells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

T cell vaccines against Mycobacterium tuberculosis (Mtb) and other pathogens are based on the principle that memory T cells rapidly generate effector responses upon challenge, leading to pathogen clearance. Despite eliciting a robust memory CD8(+) T cell response to the immunodominant Mtb antigen TB...

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Detalles Bibliográficos
Autores principales:	Carpenter, Stephen M., Nunes-Alves, Cláudio, Booty, Matthew G., Way, Sing Sing, Behar, Samuel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706326/ https://www.ncbi.nlm.nih.gov/pubmed/26745507 http://dx.doi.org/10.1371/journal.ppat.1005380

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