PLGA-Curcumin Attenuates Opioid-Induced Hyperalgesia and Inhibits Spinal CaMKIIα

Opioid-induced hyperalgesia (OIH) is one of the major problems associated with prolonged use of opioids for the treatment of chronic pain. Effective treatment for OIH is lacking. In this study, we examined the efficacy and preliminary mechanism of curcumin in attenuating OIH. We employed a newly dev...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoyu, Huang, Fang, Szymusiak, Magdalena, Tian, Xuebi, Liu, Ying, Wang, Zaijie Jim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706327/
https://www.ncbi.nlm.nih.gov/pubmed/26744842
http://dx.doi.org/10.1371/journal.pone.0146393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706327/
https://www.ncbi.nlm.nih.gov/pubmed/26744842
http://dx.doi.org/10.1371/journal.pone.0146393

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