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The Establishment of a Hyperactive Structure Allows the Tumour Suppressor Protein p53 to Function through P-TEFb during Limited CDK9 Kinase Inhibition

CDK9 is the catalytic subunit of positive elongation factor b (P-TEFb) that controls the transition of RNA polymerase II (RNAPII) into elongation. CDK9 inhibitors block mRNA synthesis and trigger activation of the stress-sensitive p53 protein. This in turn induces transcription of CDKN1A (p21) and o...

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Detalles Bibliográficos
Autores principales: Albert, Thomas K., Antrecht, Claudia, Kremmer, Elisabeth, Meisterernst, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706356/
https://www.ncbi.nlm.nih.gov/pubmed/26745862
http://dx.doi.org/10.1371/journal.pone.0146648

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