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Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells

The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by...

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Autores principales: Moraes, João Alfredo, Frony, Ana Clara, Dias, Aline Maria, Renovato-Martins, Mariana, Rodrigues, Genilson, Marcinkiewicz, Cezary, Assreuy, Jamil, Barja-Fidalgo, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706604/
https://www.ncbi.nlm.nih.gov/pubmed/26862579
http://dx.doi.org/10.1016/j.dib.2015.11.053
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author Moraes, João Alfredo
Frony, Ana Clara
Dias, Aline Maria
Renovato-Martins, Mariana
Rodrigues, Genilson
Marcinkiewicz, Cezary
Assreuy, Jamil
Barja-Fidalgo, Christina
author_facet Moraes, João Alfredo
Frony, Ana Clara
Dias, Aline Maria
Renovato-Martins, Mariana
Rodrigues, Genilson
Marcinkiewicz, Cezary
Assreuy, Jamil
Barja-Fidalgo, Christina
author_sort Moraes, João Alfredo
collection PubMed
description The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by alpha1beta1 integrin. Ang II also stimulates ROS production in VSMC via p47(phox), a NOX2 subunit. Furthermore, Ang II effect on VSMC migration was also inhibited by NOX2 inhibitor. We showed that obtustatin, alpha1beta1 integrin blocker, inhibited Ang II effect on p47(phox) activation. Ang II effect on ROS production is also PI3K dependent. Finally we showed that NOX1 and Integrin-Linked-Kinase (ILK) are crucial to NOX2 activation. The research provides information about the sequential events of NOX1/alpha1beta1 integrin/ILK/NOX2 in Ang II effects on VSMC.
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spelling pubmed-47066042016-02-09 Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells Moraes, João Alfredo Frony, Ana Clara Dias, Aline Maria Renovato-Martins, Mariana Rodrigues, Genilson Marcinkiewicz, Cezary Assreuy, Jamil Barja-Fidalgo, Christina Data Brief Data Article The data provides information in support of the research article Moraes et al., Atherosclerosis 243(2) (2015) 477–485 [1]. Here we provide data behind the mechanisms involved in Angiotensin II (Ang II) effects on vascular smooth muscle cells (VSMC). Ang II-induced VSMC ROS production is modulated by alpha1beta1 integrin. Ang II also stimulates ROS production in VSMC via p47(phox), a NOX2 subunit. Furthermore, Ang II effect on VSMC migration was also inhibited by NOX2 inhibitor. We showed that obtustatin, alpha1beta1 integrin blocker, inhibited Ang II effect on p47(phox) activation. Ang II effect on ROS production is also PI3K dependent. Finally we showed that NOX1 and Integrin-Linked-Kinase (ILK) are crucial to NOX2 activation. The research provides information about the sequential events of NOX1/alpha1beta1 integrin/ILK/NOX2 in Ang II effects on VSMC. Elsevier 2015-12-17 /pmc/articles/PMC4706604/ /pubmed/26862579 http://dx.doi.org/10.1016/j.dib.2015.11.053 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Moraes, João Alfredo
Frony, Ana Clara
Dias, Aline Maria
Renovato-Martins, Mariana
Rodrigues, Genilson
Marcinkiewicz, Cezary
Assreuy, Jamil
Barja-Fidalgo, Christina
Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_full Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_fullStr Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_full_unstemmed Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_short Data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin II effects in vascular smooth muscle cells
title_sort data in support of alpha1beta1 and integrin-linked kinase interact and modulate angiotensin ii effects in vascular smooth muscle cells
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706604/
https://www.ncbi.nlm.nih.gov/pubmed/26862579
http://dx.doi.org/10.1016/j.dib.2015.11.053
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