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Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients
BACKGROUND: Blood pressure (BP) variability is associated with target organ damage in hypertension and diabetes. The 24 h ambulatory blood pressure monitoring (24 h-ABPM) has been proposed as an evaluation for BP variability using several indexes [standard deviation (SD) of mean BP, coefficient of v...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706684/ https://www.ncbi.nlm.nih.gov/pubmed/26747793 http://dx.doi.org/10.1186/s12872-015-0183-1 |
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author | Massierer, Daniela Leiria, Liana Farias Severo, Mateus Dorneles Ledur, Priscila Dos Santos Becker, Alexandre Dalpiaz Aguiar, Fernanda Mus Lima, Eliandra Freitas, Valéria Centeno Schaan, Beatriz D. Gus, Miguel |
author_facet | Massierer, Daniela Leiria, Liana Farias Severo, Mateus Dorneles Ledur, Priscila Dos Santos Becker, Alexandre Dalpiaz Aguiar, Fernanda Mus Lima, Eliandra Freitas, Valéria Centeno Schaan, Beatriz D. Gus, Miguel |
author_sort | Massierer, Daniela |
collection | PubMed |
description | BACKGROUND: Blood pressure (BP) variability is associated with target organ damage in hypertension and diabetes. The 24 h ambulatory blood pressure monitoring (24 h-ABPM) has been proposed as an evaluation for BP variability using several indexes [standard deviation (SD) of mean BP, coefficient of variation (CV), BP variation over time (time-rate index)]. METHODS: We evaluated the association between BP variability measured by 24 h-ABPM indexes and echocardiographic variables in a cross-sectional study in 305 diabetic-hypertensive patients. RESULTS: Two groups were defined by the median (0.55 mmHg/min) of time-rate systolic BP (SBP) index and classified as low or high variability. Age was 57.3 ± 6.2 years, 196 (64.3 %) were female. Diabetes duration was 10.0 (5.0–16.2) years, HbA1c was 8.2 ± 1.9 %. Baseline clinical characteristics were similar between low (n = 148) and high (n = 157) variability groups. Office SBP and systolic 24 h-ABPM were higher in the high variability group (139.9 mmHg vs 146.0 mmHg, P = 0.006; 128.3 mmHg vs 132.9 mmHg, P = 0.019, respectively). Time-rate index, SD and CV of SBP, were higher in high variability group (P < 0.001; P < 0.001 and P = 0.003, respectively). Time-rate index was not independently associated with the echocardiography’s variables in multiple linear model when adjusting for age, 24 h-ABPM, diabetes duration and HbA1c. The multiple linear regression model revealed that the significant and independent determinants for septum thickness, relative wall thickness and posterior wall thickness (parameters of left ventricular hypertrophy) were: age (p = 0.025; p = 0.010; p = 0.032, respectively) and 24 h-SBP (p < 0.001 in the three parameters). CONCLUSION: BP variability estimated by 24 h-ABPM is not independently associated with echocardiographic parameters in diabetic-hypertensive patients. |
format | Online Article Text |
id | pubmed-4706684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-47066842016-01-10 Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients Massierer, Daniela Leiria, Liana Farias Severo, Mateus Dorneles Ledur, Priscila Dos Santos Becker, Alexandre Dalpiaz Aguiar, Fernanda Mus Lima, Eliandra Freitas, Valéria Centeno Schaan, Beatriz D. Gus, Miguel BMC Cardiovasc Disord Research Article BACKGROUND: Blood pressure (BP) variability is associated with target organ damage in hypertension and diabetes. The 24 h ambulatory blood pressure monitoring (24 h-ABPM) has been proposed as an evaluation for BP variability using several indexes [standard deviation (SD) of mean BP, coefficient of variation (CV), BP variation over time (time-rate index)]. METHODS: We evaluated the association between BP variability measured by 24 h-ABPM indexes and echocardiographic variables in a cross-sectional study in 305 diabetic-hypertensive patients. RESULTS: Two groups were defined by the median (0.55 mmHg/min) of time-rate systolic BP (SBP) index and classified as low or high variability. Age was 57.3 ± 6.2 years, 196 (64.3 %) were female. Diabetes duration was 10.0 (5.0–16.2) years, HbA1c was 8.2 ± 1.9 %. Baseline clinical characteristics were similar between low (n = 148) and high (n = 157) variability groups. Office SBP and systolic 24 h-ABPM were higher in the high variability group (139.9 mmHg vs 146.0 mmHg, P = 0.006; 128.3 mmHg vs 132.9 mmHg, P = 0.019, respectively). Time-rate index, SD and CV of SBP, were higher in high variability group (P < 0.001; P < 0.001 and P = 0.003, respectively). Time-rate index was not independently associated with the echocardiography’s variables in multiple linear model when adjusting for age, 24 h-ABPM, diabetes duration and HbA1c. The multiple linear regression model revealed that the significant and independent determinants for septum thickness, relative wall thickness and posterior wall thickness (parameters of left ventricular hypertrophy) were: age (p = 0.025; p = 0.010; p = 0.032, respectively) and 24 h-SBP (p < 0.001 in the three parameters). CONCLUSION: BP variability estimated by 24 h-ABPM is not independently associated with echocardiographic parameters in diabetic-hypertensive patients. BioMed Central 2016-01-08 /pmc/articles/PMC4706684/ /pubmed/26747793 http://dx.doi.org/10.1186/s12872-015-0183-1 Text en © Massierer et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Massierer, Daniela Leiria, Liana Farias Severo, Mateus Dorneles Ledur, Priscila Dos Santos Becker, Alexandre Dalpiaz Aguiar, Fernanda Mus Lima, Eliandra Freitas, Valéria Centeno Schaan, Beatriz D. Gus, Miguel Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title | Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title_full | Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title_fullStr | Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title_full_unstemmed | Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title_short | Blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
title_sort | blood pressure variability and its association with echocardiographic parameters in hypertensive diabetic patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706684/ https://www.ncbi.nlm.nih.gov/pubmed/26747793 http://dx.doi.org/10.1186/s12872-015-0183-1 |
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