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The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus

BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. Autoimmune thyroiditis (AT) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded DNA...

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Autores principales: Rasaei, Nakisa, Shams, Mesbah, Kamali-Sarvestani, Eskandar, Nazarinia, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706711/
https://www.ncbi.nlm.nih.gov/pubmed/26756002
http://dx.doi.org/10.5812/ircmj.17298
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author Rasaei, Nakisa
Shams, Mesbah
Kamali-Sarvestani, Eskandar
Nazarinia, Mohammad Ali
author_facet Rasaei, Nakisa
Shams, Mesbah
Kamali-Sarvestani, Eskandar
Nazarinia, Mohammad Ali
author_sort Rasaei, Nakisa
collection PubMed
description BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. Autoimmune thyroiditis (AT) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded DNA, anti-Ro antibodies and anti-cardiolipin antibodies. OBJECTIVES: The aim of this study was to evaluate the prevalence of thyroid dysfunction and thyroid auto-antibodies in patients with SLE and its relation to SLE disease and other autoantibodies. PATIENTS AND METHODS: This was a case-control study. The study included a total of 88 patients with SLE and 88 age- and sex-matched healthy volunteers as control group. Two study groups were compared regarding thyroid function test, antinuclear antibody (ANA), antibodies to double-stranded DNA (dsDNA), anti- thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase (anti-TPO) antibody. RESULTS: The mean age of SLE patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (P = 0.821). Patients had significantly higher prevalence (43.2% vs. 23.9%; P = 0.015) and titers (221.8 ± 570.5 vs. 78.2 ± 277.2; P = 0.036) of antibodies to Tg compared to controls. The patients had significantly lower titers of T3 compared to controls (125.2 ± 35.6 vs. 136.2 ± 26.5; P = 0.021). The titers of T4, TSH and anti-TPO antibody did not differ significantly between the two study groups. CONCLUSIONS: Thyroid dysfunction was not higher in SLE patients compared to healthy individuals. However, anti-Tg antibodies were higher in SLE patients. It has not yet been established that thyroid function tests should be performed routinely in SLE patients.
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spelling pubmed-47067112016-01-11 The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus Rasaei, Nakisa Shams, Mesbah Kamali-Sarvestani, Eskandar Nazarinia, Mohammad Ali Iran Red Crescent Med J Research Article BACKGROUND: Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease caused by immune system-mediated tissue damage. Autoimmune thyroiditis (AT) is an organ-specific disease associated with production of a variety of antibodies such as antinuclear antibodies, anti-double-stranded DNA, anti-Ro antibodies and anti-cardiolipin antibodies. OBJECTIVES: The aim of this study was to evaluate the prevalence of thyroid dysfunction and thyroid auto-antibodies in patients with SLE and its relation to SLE disease and other autoantibodies. PATIENTS AND METHODS: This was a case-control study. The study included a total of 88 patients with SLE and 88 age- and sex-matched healthy volunteers as control group. Two study groups were compared regarding thyroid function test, antinuclear antibody (ANA), antibodies to double-stranded DNA (dsDNA), anti- thyroglobulin antibody (anti-Tg), and anti-thyroid peroxidase (anti-TPO) antibody. RESULTS: The mean age of SLE patients and controls were 32.16 ± 9.19 and 32.48 ± 9.47 years, respectively (P = 0.821). Patients had significantly higher prevalence (43.2% vs. 23.9%; P = 0.015) and titers (221.8 ± 570.5 vs. 78.2 ± 277.2; P = 0.036) of antibodies to Tg compared to controls. The patients had significantly lower titers of T3 compared to controls (125.2 ± 35.6 vs. 136.2 ± 26.5; P = 0.021). The titers of T4, TSH and anti-TPO antibody did not differ significantly between the two study groups. CONCLUSIONS: Thyroid dysfunction was not higher in SLE patients compared to healthy individuals. However, anti-Tg antibodies were higher in SLE patients. It has not yet been established that thyroid function tests should be performed routinely in SLE patients. Kowsar 2015-12-05 /pmc/articles/PMC4706711/ /pubmed/26756002 http://dx.doi.org/10.5812/ircmj.17298 Text en Copyright © 2015, Iranian Red Crescent Medical Journal. http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Rasaei, Nakisa
Shams, Mesbah
Kamali-Sarvestani, Eskandar
Nazarinia, Mohammad Ali
The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title_full The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title_fullStr The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title_full_unstemmed The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title_short The Prevalence of Thyroid Dysfunction in Patients With Systemic Lupus Erythematosus
title_sort prevalence of thyroid dysfunction in patients with systemic lupus erythematosus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706711/
https://www.ncbi.nlm.nih.gov/pubmed/26756002
http://dx.doi.org/10.5812/ircmj.17298
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