Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4

Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels q...

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Autores principales: Lukasz, Alexander, Beneke, Jan, Thamm, Kristina, Kielstein, Jan T., Menne, Jan, Mikesch, Jan-Henrik, Schmidt, Bernhard M. W., Haller, Hermann, Kümpers, Philipp, David, Sascha, Schiffer, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706916/
https://www.ncbi.nlm.nih.gov/pubmed/26858516
http://dx.doi.org/10.1155/2015/670248
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author Lukasz, Alexander
Beneke, Jan
Thamm, Kristina
Kielstein, Jan T.
Menne, Jan
Mikesch, Jan-Henrik
Schmidt, Bernhard M. W.
Haller, Hermann
Kümpers, Philipp
David, Sascha
Schiffer, Mario
author_facet Lukasz, Alexander
Beneke, Jan
Thamm, Kristina
Kielstein, Jan T.
Menne, Jan
Mikesch, Jan-Henrik
Schmidt, Bernhard M. W.
Haller, Hermann
Kümpers, Philipp
David, Sascha
Schiffer, Mario
author_sort Lukasz, Alexander
collection PubMed
description Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels quantified in 48 adult HUS patients were predictive for a complicated clinical course, in particular for need of hemodialysis and mechanical ventilation as well as occurrence of seizures. In vitro challenge of human umbilical vein endothelial cells with patients' sera indicated an injurious mediator role of Angpt-2 opening future perspectives for mitigating endothelial activation in HUS.
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spelling pubmed-47069162016-02-08 Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4 Lukasz, Alexander Beneke, Jan Thamm, Kristina Kielstein, Jan T. Menne, Jan Mikesch, Jan-Henrik Schmidt, Bernhard M. W. Haller, Hermann Kümpers, Philipp David, Sascha Schiffer, Mario Mediators Inflamm Clinical Study Escherichia coli O104:H4-associated hemolytic uremic syndrome (HUS) is characterized by Shiga toxin-induced vascular damage. As indicated by recent studies, dysregulation of the angiopoietin (Angpt)/Tie2 ligand receptor system may be crucial for endothelial dysfunction in HUS. Early Angpt-2 levels quantified in 48 adult HUS patients were predictive for a complicated clinical course, in particular for need of hemodialysis and mechanical ventilation as well as occurrence of seizures. In vitro challenge of human umbilical vein endothelial cells with patients' sera indicated an injurious mediator role of Angpt-2 opening future perspectives for mitigating endothelial activation in HUS. Hindawi Publishing Corporation 2015 2015-12-24 /pmc/articles/PMC4706916/ /pubmed/26858516 http://dx.doi.org/10.1155/2015/670248 Text en Copyright © 2015 Alexander Lukasz et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Lukasz, Alexander
Beneke, Jan
Thamm, Kristina
Kielstein, Jan T.
Menne, Jan
Mikesch, Jan-Henrik
Schmidt, Bernhard M. W.
Haller, Hermann
Kümpers, Philipp
David, Sascha
Schiffer, Mario
Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title_full Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title_fullStr Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title_full_unstemmed Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title_short Involvement of Angiopoietin-2 and Tie2 Receptor Phosphorylation in STEC-HUS Mediated by Escherichia coli O104:H4
title_sort involvement of angiopoietin-2 and tie2 receptor phosphorylation in stec-hus mediated by escherichia coli o104:h4
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706916/
https://www.ncbi.nlm.nih.gov/pubmed/26858516
http://dx.doi.org/10.1155/2015/670248
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