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The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response

MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn's disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE t...

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Autores principales: Moy, Matthew P., Sauk, Jenny, Gee, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706951/
https://www.ncbi.nlm.nih.gov/pubmed/26819611
http://dx.doi.org/10.1155/2016/8168695
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author Moy, Matthew P.
Sauk, Jenny
Gee, Michael S.
author_facet Moy, Matthew P.
Sauk, Jenny
Gee, Michael S.
author_sort Moy, Matthew P.
collection PubMed
description MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn's disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD.
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spelling pubmed-47069512016-01-27 The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response Moy, Matthew P. Sauk, Jenny Gee, Michael S. Gastroenterol Res Pract Review Article MR enterography (MRE) has become the primary imaging modality in the assessment of Crohn's disease (CD) in both children and adults at many institutions in the United States and worldwide, primarily due to its noninvasiveness, superior soft tissue contrast, and lack of ionizing radiation. MRE technique includes distention of the small bowel with oral contrast media with the acquisition of T2-weighted, balanced steady-state free precession, and multiphase T1-weighted fat suppressed gadolinium contrast-enhanced sequences. With the introduction of molecule-targeted biologic agents into the clinical setting for CD and their potential to reverse the inflammatory process, MRE is increasingly utilized to evaluate disease activity and response to therapy as an imaging complement to clinical indices or optical endoscopy. New and emerging MRE techniques, such as diffusion-weighted imaging (DWI), magnetization transfer, ultrasmall superparamagnetic iron oxide- (USPIO-) enhanced MRI, and PET-MR, offer the potential for an expanded role of MRI in detecting occult disease activity, evaluating early treatment response/resistance, and differentiating inflammatory from fibrotic strictures. Familiarity with MR enterography is essential for radiologists and gastroenterologists as the technique evolves and is further incorporated into the clinical management of CD. Hindawi Publishing Corporation 2016 2015-12-27 /pmc/articles/PMC4706951/ /pubmed/26819611 http://dx.doi.org/10.1155/2016/8168695 Text en Copyright © 2016 Matthew P. Moy et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Moy, Matthew P.
Sauk, Jenny
Gee, Michael S.
The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title_full The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title_fullStr The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title_full_unstemmed The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title_short The Role of MR Enterography in Assessing Crohn's Disease Activity and Treatment Response
title_sort role of mr enterography in assessing crohn's disease activity and treatment response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706951/
https://www.ncbi.nlm.nih.gov/pubmed/26819611
http://dx.doi.org/10.1155/2016/8168695
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