Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model

Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of loc...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Mu, Dong, Jian-Xin, Li, Lu-Bin, Che, Hai-Jie, Yong, Jun, Song, Fu-Bo, Wang, Tao, Zhang, Jv-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706963/
https://www.ncbi.nlm.nih.gov/pubmed/26819600
http://dx.doi.org/10.1155/2016/2604032
_version_ 1782409243645706240
author Yang, Mu
Dong, Jian-Xin
Li, Lu-Bin
Che, Hai-Jie
Yong, Jun
Song, Fu-Bo
Wang, Tao
Zhang, Jv-Wen
author_facet Yang, Mu
Dong, Jian-Xin
Li, Lu-Bin
Che, Hai-Jie
Yong, Jun
Song, Fu-Bo
Wang, Tao
Zhang, Jv-Wen
author_sort Yang, Mu
collection PubMed
description Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.
format Online
Article
Text
id pubmed-4706963
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-47069632016-01-27 Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model Yang, Mu Dong, Jian-Xin Li, Lu-Bin Che, Hai-Jie Yong, Jun Song, Fu-Bo Wang, Tao Zhang, Jv-Wen Gastroenterol Res Pract Research Article Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis. Hindawi Publishing Corporation 2016 2015-12-27 /pmc/articles/PMC4706963/ /pubmed/26819600 http://dx.doi.org/10.1155/2016/2604032 Text en Copyright © 2016 Mu Yang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Yang, Mu
Dong, Jian-Xin
Li, Lu-Bin
Che, Hai-Jie
Yong, Jun
Song, Fu-Bo
Wang, Tao
Zhang, Jv-Wen
Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_full Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_fullStr Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_full_unstemmed Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_short Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
title_sort local and remote postconditioning decrease intestinal injury in a rabbit ischemia/reperfusion model
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4706963/
https://www.ncbi.nlm.nih.gov/pubmed/26819600
http://dx.doi.org/10.1155/2016/2604032
work_keys_str_mv AT yangmu localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT dongjianxin localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT lilubin localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT chehaijie localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT yongjun localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT songfubo localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT wangtao localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel
AT zhangjvwen localandremotepostconditioningdecreaseintestinalinjuryinarabbitischemiareperfusionmodel

Ejemplares similares