Cargando…
Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body
The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylpredni...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Association for Laboratory Animal Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707146/ https://www.ncbi.nlm.nih.gov/pubmed/26755921 http://dx.doi.org/10.5625/lar.2015.31.4.180 |
_version_ | 1782409259017830400 |
---|---|
author | Najar, Azam Fridoni, Mohammadjavad Rezaei, Fatemesadat Bayat, Saba Bayat, Mohammad |
author_facet | Najar, Azam Fridoni, Mohammadjavad Rezaei, Fatemesadat Bayat, Saba Bayat, Mohammad |
author_sort | Najar, Azam |
collection | PubMed |
description | The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three times per week), dexamethasone (0.7 mg/kg three times per week, and low-level laser treated rats. Lumbar vertebrae in rats were exposed to the pulsed laser. We conducted a biomechanical test to examine the mechanical properties of vertebral body in rats' lumbar bone. Supraphysiologic glucocorticoid administration protocols did not impair the biomechanical properties of rats' vertebral bodies compared to control and laser-treated rats. Supraphysiologic glucocorticoid administration caused an anabolic effect on the vertebral bodies. |
format | Online Article Text |
id | pubmed-4707146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-47071462016-01-11 Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body Najar, Azam Fridoni, Mohammadjavad Rezaei, Fatemesadat Bayat, Saba Bayat, Mohammad Lab Anim Res Original Article The aim of this study is to assess the effects of different glucocorticoid administration protocols on biomechanical properties of the first lumbar vertebral body in rats. We divided 40 male rats into the following groups: control, dexamethasone (7 mg/week), dexamethasone (0.7 mg/week), methylprednisolone (7 mg/kg/week), methylprednisolone (5 mg/kg twice weekly), dexamethasone (7 mg/kg three times per week), dexamethasone (0.7 mg/kg three times per week, and low-level laser treated rats. Lumbar vertebrae in rats were exposed to the pulsed laser. We conducted a biomechanical test to examine the mechanical properties of vertebral body in rats' lumbar bone. Supraphysiologic glucocorticoid administration protocols did not impair the biomechanical properties of rats' vertebral bodies compared to control and laser-treated rats. Supraphysiologic glucocorticoid administration caused an anabolic effect on the vertebral bodies. Korean Association for Laboratory Animal Science 2015-12 2015-12-22 /pmc/articles/PMC4707146/ /pubmed/26755921 http://dx.doi.org/10.5625/lar.2015.31.4.180 Text en Copyright © 2015 Korean Association for Laboratory Animal Science http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Najar, Azam Fridoni, Mohammadjavad Rezaei, Fatemesadat Bayat, Saba Bayat, Mohammad Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title | Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title_full | Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title_fullStr | Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title_full_unstemmed | Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title_short | Supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
title_sort | supraphysiologic glucocorticoid administration increased biomechanical bone strength of rats' vertebral body |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707146/ https://www.ncbi.nlm.nih.gov/pubmed/26755921 http://dx.doi.org/10.5625/lar.2015.31.4.180 |
work_keys_str_mv | AT najarazam supraphysiologicglucocorticoidadministrationincreasedbiomechanicalbonestrengthofratsvertebralbody AT fridonimohammadjavad supraphysiologicglucocorticoidadministrationincreasedbiomechanicalbonestrengthofratsvertebralbody AT rezaeifatemesadat supraphysiologicglucocorticoidadministrationincreasedbiomechanicalbonestrengthofratsvertebralbody AT bayatsaba supraphysiologicglucocorticoidadministrationincreasedbiomechanicalbonestrengthofratsvertebralbody AT bayatmohammad supraphysiologicglucocorticoidadministrationincreasedbiomechanicalbonestrengthofratsvertebralbody |