Spinal Muscular Atrophy Patient iPSC-Derived Motor Neurons Have Reduced Expression of Proteins Important in Neuronal Development

Spinal muscular atrophy (SMA) is an inherited neuromuscular disease primarily characterized by degeneration of spinal motor neurons, and caused by reduced levels of the SMN protein. Previous studies to understand the proteomic consequences of reduced SMN have mostly utilized patient fibroblasts and...

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Detalles Bibliográficos
Autores principales: Fuller, Heidi R., Mandefro, Berhan, Shirran, Sally L., Gross, Andrew R., Kaus, Anjoscha S., Botting, Catherine H., Morris, Glenn E., Sareen, Dhruv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707261/
https://www.ncbi.nlm.nih.gov/pubmed/26793058
http://dx.doi.org/10.3389/fncel.2015.00506

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