Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress

We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H(2)O(2)-mediated hepatocyte injury, the e...

Descripción completa

Detalles Bibliográficos
Autores principales: Jadeja, Ravirajsinh N., Urrunaga, Nathalie H., Ahmad, Daniel, Khurana, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707288/
https://www.ncbi.nlm.nih.gov/pubmed/26862589
http://dx.doi.org/10.1016/j.dib.2015.12.025
Descripción
Sumario:We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H(2)O(2)-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H(2)O(2)–treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.

Ejemplares similares