Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress

We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H(2)O(2)-mediated hepatocyte injury, the e...

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Autores principales: Jadeja, Ravirajsinh N., Urrunaga, Nathalie H., Ahmad, Daniel, Khurana, Sandeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Data Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707288/
https://www.ncbi.nlm.nih.gov/pubmed/26862589
http://dx.doi.org/10.1016/j.dib.2015.12.025
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author Jadeja, Ravirajsinh N.
Urrunaga, Nathalie H.
Ahmad, Daniel
Khurana, Sandeep
author_facet Jadeja, Ravirajsinh N.
Urrunaga, Nathalie H.
Ahmad, Daniel
Khurana, Sandeep
author_sort Jadeja, Ravirajsinh N.
collection PubMed
description We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H(2)O(2)-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H(2)O(2)–treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice.
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spelling pubmed-47072882016-02-09 Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress Jadeja, Ravirajsinh N. Urrunaga, Nathalie H. Ahmad, Daniel Khurana, Sandeep Data Brief Data Article We recently demonstrated the role of M1 muscarinic receptors (M1R) in modulating oxidative stress in liver and hepatocytes (Urrunaga et al., 2015) [1]. Here we provide data regarding the effect of a novel M1R agonist, VU0357017 (Lebois et al., 2010) [2], on H(2)O(2)-mediated hepatocyte injury, the effect of an M1R antagonist VU0255035 (Sheffler et al., 2009) [3] on catalase and super oxide dismutase (SOD) activities in H(2)O(2)–treated hepatocytes in vitro, and finally, the effect of M1R ablation on hepatic catalase activity in acetaminophen (APAP)-treated mice. Elsevier 2015-12-18 /pmc/articles/PMC4707288/ /pubmed/26862589 http://dx.doi.org/10.1016/j.dib.2015.12.025 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Data Article
Jadeja, Ravirajsinh N.
Urrunaga, Nathalie H.
Ahmad, Daniel
Khurana, Sandeep
Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title_full Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title_fullStr Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title_full_unstemmed Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title_short Data regarding M1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
title_sort data regarding m1 muscarinic receptor-mediated modulation of hepatic catalase activity in response to oxidative stress
topic Data Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707288/
https://www.ncbi.nlm.nih.gov/pubmed/26862589
http://dx.doi.org/10.1016/j.dib.2015.12.025
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