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An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of the pancreatic islet beta cells. Multiple genetic loci contribute to disease susceptibility in humans, with the most responsible locus being the major histocompatibility complex (MHC). Certain MHC alleles...

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Detalles Bibliográficos
Autores principales:	Babad, Jeffrey, Ali, Riyasat, Schloss, Jennifer, DiLorenzo, Teresa P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707332/ https://www.ncbi.nlm.nih.gov/pubmed/26824049 http://dx.doi.org/10.1155/2016/7959060

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