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Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients

Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple an...

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Autores principales: Bartáková, Vendula, Klimešová, Linda, Kianičková, Katarína, Dvořáková, Veronika, Malúšková, Denisa, Řehořová, Jitka, Svojanovský, Jan, Olšovský, Jindřich, Bělobrádková, Jana, Kaňková, Kateřina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707347/
https://www.ncbi.nlm.nih.gov/pubmed/26824046
http://dx.doi.org/10.1155/2016/6726492
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author Bartáková, Vendula
Klimešová, Linda
Kianičková, Katarína
Dvořáková, Veronika
Malúšková, Denisa
Řehořová, Jitka
Svojanovský, Jan
Olšovský, Jindřich
Bělobrádková, Jana
Kaňková, Kateřina
author_facet Bartáková, Vendula
Klimešová, Linda
Kianičková, Katarína
Dvořáková, Veronika
Malúšková, Denisa
Řehořová, Jitka
Svojanovský, Jan
Olšovský, Jindřich
Bělobrádková, Jana
Kaňková, Kateřina
author_sort Bartáková, Vendula
collection PubMed
description Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR </≥65 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic.
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spelling pubmed-47073472016-01-28 Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients Bartáková, Vendula Klimešová, Linda Kianičková, Katarína Dvořáková, Veronika Malúšková, Denisa Řehořová, Jitka Svojanovský, Jan Olšovský, Jindřich Bělobrádková, Jana Kaňková, Kateřina J Diabetes Res Research Article Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes in T2DM patients. A total of 421 T2DM patients with variable baseline stage of diabetic kidney disease (DKD) were prospectively followed. A history of the cardiovascular disease was present in 81 (19.2%) patients at baseline, and DKD (glomerular filtration rate < 60 mL/min or proteinuria) was present in 328 (77.9%) at baseline. Progressive renal decline was defined as a continuous rate of glomerular filtration rate loss ≥ 3.3% per year. Resting heart rate was not significantly higher in subjects with cardiovascular disease or DKD at baseline compared to those without. Using time-to-event analyses, significant differences in the cumulative incidence of the studied outcomes, that is, progression of DKD (and specifically progressive renal decline), major advanced cardiovascular event, and all-cause mortality, between RHR </≥65 (arbitrary cut-off) and 75 (median) bpm were not found. We did not ascertain predictive value of the RHR for the renal or cardiovascular outcomes in T2DM subjects in Czech Republic. Hindawi Publishing Corporation 2016 2015-12-28 /pmc/articles/PMC4707347/ /pubmed/26824046 http://dx.doi.org/10.1155/2016/6726492 Text en Copyright © 2016 Vendula Bartáková et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bartáková, Vendula
Klimešová, Linda
Kianičková, Katarína
Dvořáková, Veronika
Malúšková, Denisa
Řehořová, Jitka
Svojanovský, Jan
Olšovský, Jindřich
Bělobrádková, Jana
Kaňková, Kateřina
Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title_full Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title_fullStr Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title_full_unstemmed Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title_short Resting Heart Rate Does Not Predict Cardiovascular and Renal Outcomes in Type 2 Diabetic Patients
title_sort resting heart rate does not predict cardiovascular and renal outcomes in type 2 diabetic patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4707347/
https://www.ncbi.nlm.nih.gov/pubmed/26824046
http://dx.doi.org/10.1155/2016/6726492
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